He returned to Marvel to pencil books like Thunderbolts, the Daredevil Movie Adaptation, the Mystique ongoing, and Spider-Man: Breakout. After starting the ongoing Marvel Adv. The Avengers, doing the post-Civil War issues of Black Panther (World Tour), and the MAX: Wisdom miniseries, he moved over to DC Comics, where he did books like Countdown, All-Flash, Checkmate, or Crime Bible. He returned to Marvel last year with the House of M: Masters of Evil and Dark Avengers: Ares miniseries, and the Indomitable Iron Man B & W one-shot. Also for Marvel, he pencilled Iron Man: Noir, Black Widow, and the Supreme Power miniseries.
Manuel is currently penciling Bloodshot as part of the Valiant Entertainment relaunch.